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Linear mixed models for skew-normal/independent bivariate responses with an application to periodontal disease

Dipankar Bandyopadhyay, Victor H Lachos, Carlos A Abanto-Valle & Pulak Ghosh
Journal Name
Statistics in Medicine
Journal Publication
others
Publication Year
2010
Journal Publications Functional Area
Decision Sciences and Information Systems
Publication Date
Vol. 29, No. 25, PP 2643-2655, 2010
Abstract

Bivariate clustered (correlated) data often encountered in epidemiological and clinical research are routinely analyzed uneer a linear mixed model (LMM) framework with underlying normality assumptions of the random effects and within-subject errors. However, such normality assumptions might be questionable if the data set particularly exhibits skewness and heavy tails. Using a Bayesian paradigm, we use the skew-normal/independent (SNI) distribution as a tool for modeling clustered data with bivariate non-normal responses in an LMM framework.

Linear mixed models for skew-normal/independent bivariate responses with an application to periodontal disease

Author(s) Name: Dipankar Bandyopadhyay, Victor H Lachos, Carlos A Abanto-Valle & Pulak Ghosh
Journal Name: Statistics in Medicine
Volume: Vol. 29, No. 25, PP 2643-2655, 2010
Year of Publication: 2010
Abstract:

Bivariate clustered (correlated) data often encountered in epidemiological and clinical research are routinely analyzed uneer a linear mixed model (LMM) framework with underlying normality assumptions of the random effects and within-subject errors. However, such normality assumptions might be questionable if the data set particularly exhibits skewness and heavy tails. Using a Bayesian paradigm, we use the skew-normal/independent (SNI) distribution as a tool for modeling clustered data with bivariate non-normal responses in an LMM framework.