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Dynamic resource scheduling of biomanufacturing projects

Yasemin Limon and Ananth Krishnamurthy
Journal Name
Computers & Industrial Engineering
Journal Publication
others
Publication Year
2020
Journal Publications Functional Area
Decision Sciences
Publication Date
Vol. 147, September 2020, 106527, Pg. 1-11
Abstract

We consider the scheduling problem for biomanufacturing projects that involve multiple tasks and “no-wait” constraints between some of these tasks. The aim is to create schedules that ensure timely delivery of products while enabling schedule revisions to accommodate additional constraints realized during the execution of these projects. We formulate the problem as a mixed-integer linear programming model with the objective of minimizing total tardiness, and propose a dynamic scheduling approach that solves a series of modified mixed-integer linear programming models to revise and improve the schedule. We conduct numerical studies to investigate the performance of this approach and compare its performance to a traditional proactive scheduling approach. In collaboration with biomanufacturing companies, we create a scheduling tool and validate the approach with implementation in an industry setting.

Dynamic resource scheduling of biomanufacturing projects

Author(s) Name: Yasemin Limon and Ananth Krishnamurthy
Journal Name: Computers & Industrial Engineering
Volume: Vol. 147, September 2020, 106527, Pg. 1-11
Year of Publication: 2020
Abstract:

We consider the scheduling problem for biomanufacturing projects that involve multiple tasks and “no-wait” constraints between some of these tasks. The aim is to create schedules that ensure timely delivery of products while enabling schedule revisions to accommodate additional constraints realized during the execution of these projects. We formulate the problem as a mixed-integer linear programming model with the objective of minimizing total tardiness, and propose a dynamic scheduling approach that solves a series of modified mixed-integer linear programming models to revise and improve the schedule. We conduct numerical studies to investigate the performance of this approach and compare its performance to a traditional proactive scheduling approach. In collaboration with biomanufacturing companies, we create a scheduling tool and validate the approach with implementation in an industry setting.